Also known as regenerative injection therapy, prolotherapy is a procedure that stimulates the body’s natural healing process. It is a non-surgical treatment using the injection of a dextrose solution into an injured tendon or ligament to cause irritation for the purpose of stimulating the body’s natural healing process in order to strengthen weakened areas, improve function, and reduce pain. The dextrose, which is an irritant, is hypothesized to initiate a mild inflammatory process to recruit the body’s natural repair mechanisms andstart the healing cascade. The result is repair and growth of new ligament and tendon fibers that strengthen lax, weakened, or elongated tendons to restore strength and function. Prolotherapy can be effective in treating pain syndromes associated with lax, weakened, orelongated tendons and ligaments in a variety of areas including the neck, back, sacroiliac joint, knee, shoulder, hip, and elbow. The procedure is simple and is performed in the office.