Emil Zeynalov, M.D.

Emil

Contact: 303-789-8960

Email: emil.zeynalov@healthonecares.com

The beginning of my career was devoted to medical practice of anesthesiology and critical care medicine. However, my interests always extended beyond practice which brought me to neuroscience research. My knowledge of clinical demands was augmented by scientific training in neuroscience research and teaching of basic sciences in academic settings. I completed my postdoctoral fellowship at the Cleveland Clinic and Johns Hopkins University where I was drawn by the stroke research field. My work resulted in numerous publications in the relevant areas of research. I continue to improve my science skills as a medical researcher at the Swedish Medical Center Colorado where I combine practical science approaches with theoretical methods. My research background helped develop and implement new ideas in stroke research which allows me to continuously grow as a professional.

 

Education

1987–1994: Azerbaijan State Medical University—MD

Baku, Azerbaijan

 

Postgraduate Training

2004–2009: Postdoctoral Fellow, Department of Anesthesiology and Critical Care Medicine Johns Hopkins University, School of Medicine, Baltimore, Maryland

2002 – 2004: Postdoctoral Fellow, Department of Neurosurgery

The Cleveland Clinic Foundation, Cleveland, Ohio

1995–1998: Resident Doctor, Dept. of Anesthesiology and Critical Care Medicine

Hospital of Internal Affairs # 12576, Baku, Azerbaijan

1994–1995: Internship, Department of Anesthesiology and Critical Care Medicine,

Clinical Research Institute of Experimental Surgery,

Baku, Azerbaijan

 

 Faculty Appointments

2015-Present: Adjunct Faculty, National American University. Denver, Colorado

2013-Present: Medical Researcher, Department of Neurotrauma Research, Swedish Medical Center, Englewood, Colorado

2010-2013: Instructor, Uniformed Services University of the Health Sciences School of Medicine, Bethesda, Maryland

2009-2013: Senior Research Associate, Uniformed Services University Graduate School of Nursing, Bethesda, Maryland

2009: Jan-Nov Research Associate, Department of Anesthesiology and Critical Care Medicine Johns Hopkins University, School of Medicine, Baltimore, Maryland

 

Honors and Awards

 

2015: Society of Critical Care Medicine Neuroscience Section Travel Grant for 2015 Annual Congress, Phoenix AZ

2011-2012: Pilot grant from the Henry M. Jackson Foundation. Title: Gender-Specific Differences in Regional Cerebral Blood Flow and Glucose Metabolism after Moderate Lateral Fluid Percussion Injury. Total direct cost: $100,449

2006–2008: Ruth L. Kirshstein National Research Service Award

NIH Clinician-Scientist Award T-32, ID No: GM075774-02. Total direct cost: $225,000

 

Peer-reviewed Publications

1. Zeynalov, E, Jones, SM. Recent Advances and Future Directions in Preclinical Research of AVP Receptor Blocker Conivaptan in the Context of Stroke. Neural Regeneration Research, In Press 2016

2. Zeynalov, E, Jones, SM, Elliott, JP. Continuous IV Infusion is the Choice Treatment Route for Arginine-Vasopressin Receptor Blocker Conivaptan in Mice to Study Stroke-Evoked Brain Edema, Journal of Visualized Experiments, In Press 2016

3. Zeynalov, E, Jones, SM, Seo, JW, Snell L, Elliott, JP. Arginine-Vasopressin Receptor Blocker Conivaptan Reduces Brain Edema and Blood-Brain Barrier Disruption after Experimental Stroke in Mice. PLOS ONE, Aug 14 2015

4. Zeynalov E, Rezvani N, Miyazaki C, Liu X, Littleton-Kearney MT. Reproductive Senescence Blunts Response of Estrogen Receptor-α Expression to Estrogen Treatment in Rat Postischemic Cerebral Microvessels. PLOS ONE, 9(7), Jul 10, 2014

5. Miyazaki C, Zeynalov E, Koehler, RC, Litleton-Kearney MT. Effects of delayed estrogen treatment and 20-HETE synthesis inhibition on postischemic pial artery response to acetylcholine in rats. OJMIP, 4, 1-10, 2014

6. Rezvani N, Blokhin A, Zeynalov E, Littleton-Kearney MT. Imaging of estrogen receptor-α in rat pial arterioles using a digital immunofluorescent microscope. JOVE 2011

7. Mustafa A, Ahmad A, Zeynalov E, Gazi S, Sikka G, Ehmsen J, Barrow R, Coyle J, Snyder S, and Doré S. Serine Racemase Deletion Protects Against Cerebral Ischemia And Excitotoxicity. J Neurosci 30(4): 1413-6, 2010

8. Wang G, Guo Q, Hossain M, Fazio V, Zeynalov E, Janigro D, Mayberg MR, Namura S. Bone marrow-derived cells are the major source of MMP-9 contributing to blood-brain barrier dysfunction and infarct formation after ischemic stroke in mice. Brain Res, 1294: 183-92, 2009

9. Zeynalov E, Shah Z, Li R, Doré, S. Heme oxygenase-1 is associated with neuroprotection in ischemic preconditioning. Neurobiol Dis, 35(2):264-9, 2009.

10. Li M, Zeynalov E, Li X, Miyasaki C, Koehler RC, Littleton-Kearney MT. Effects of estrogen on postischemic pial artery reactivity to ADP. Microcirculation, 4:1-11, 2009.

11. Zeynalov E, Doré, S. Low Doses of Carbon Monoxide Protect Against Experimental Focal Brain Ischemia. Neurotoxicity Research, 15(2): 133-7, 2009.

12. Zeynalov E, Chen C, Adams M, Froehner S, Ottersen OP, Amiry-Moghaddam M, Bhardwaj A. The perivascular pool of aquaporin-4 mediates the effect of osmotherapy in post-ischemic cerebral edema. Crit Care Med, 36(9):2634-40, 2008.

13. Frydenlund DS, Bhardwaj A, Otsuka T, Mylonakou MN, Yasumura T, Davidson K, Zeynalov E, Skare Ø, Laake P, Haug FM, Rash JE, Agre P, Ottersen OP, Amiry-Modhaddam M. Temporary loss of perivascular aquaporin-4 in neocortex after transient middle cerebral artery occlusion in mice. Proc Natl Acad Sci USA, 103(36):13532–6, 2006.

14. Zeynalov E, Nemoto A, Hurn PD, Koehler RC, Bhardwaj A. Neuroprotective effect of selective kappa opioid receptor agonist is gender specific and linked to reduced neuronal nitric oxide. J Cereb Blood Flow Metab, 26(3):414–20, 2005.

15. Thorell WE, Chow MM, Prayson RA, Shure MA, Jeon SW, Zeynalov E, Woo HH, Rasmussen PA, Rollins AM, Masaryk TJ. Optical coherence tomography: A new method to assess aneurysm healing. J Neurosurg 102(2):348–54, 2005.

 

Research Interests

Arginine-Vasopressin System in Post-Ischemic Brain Edema

Gender-specific role of kappa-receptor agonist after traumatic brain injury

Gender-specific differences in cerebral blood flow and glucose metabolism after traumatic brain injury.

Role of estrogen and estrogen receptors in cerebral blood flow and ischemia.

Roles of eicosanoids, serine racemase in neuroprotection against ischemic injury.

Neuroprotective role of carbon monoxide in transient focal brain ischemia.

Neuroprotection against ischemia/reperfusion injury provided by heme oxygenases after ischemic preconditioning.

Role of aquaporin-4 water channel in hyperosmolar therapy of stroke-induced brain edema.

Gender-specific protective role of kappa-opioid receptor agonists against transient focal brain ischemia.

Role of MEK on mice BBB disruption and experimental stroke.

Source of MMP-9 in brain ischemia.

Brain protection by resveratrol and fenofibrate against stroke in mice mediated by PPAR-α.